4Z7I

Crystal structure of insulin regulated aminopeptidase in complex with ligand

Summary for 4Z7I

Entry DOI	10.2210/pdb4z7i/pdb
Descriptor	Leucyl-cystinyl aminopeptidase, DG025 transition-state analogue enzyme inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	aminopeptidase, antigen presentation, transition-state analogue, enzyme inhibitor, hydrolase, irap
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane ; Single-pass type II membrane protein . Leucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted: Q9UIQ6
Total number of polymer chains	4
Total formula weight	217286.15
Authors	Mpakali, A.,Saridakis, E.,Harlos, K.,Zhao, Y.,Stratikos, E. (deposition date: 2015-04-07, release date: 2015-08-26, Last modification date: 2024-01-10)
Primary citation	Mpakali, A.,Saridakis, E.,Harlos, K.,Zhao, Y.,Papakyriakou, A.,Kokkala, P.,Georgiadis, D.,Stratikos, E. Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing. J Immunol., 195:2842-2851, 2015 Cited by PubMed: 26259583 DOI: 10.4049/jimmunol.1501103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.31 Å)

Structure validation