4Z7I

Crystal structure of insulin regulated aminopeptidase in complex with ligand

4Z7I の概要

• エントリーDOI: 10.2210/pdb4z7i/pdb
• 分子名称: Leucyl-cystinyl aminopeptidase, DG025 transition-state analogue enzyme inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: aminopeptidase, antigen presentation, transition-state analogue, enzyme inhibitor, hydrolase, irap
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Leucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted: Q9UIQ6
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 217286.15

構造登録者

Mpakali, A.,Saridakis, E.,Harlos, K.,Zhao, Y.,Stratikos, E. (登録日: 2015-04-07, 公開日: 2015-08-26, 最終更新日: 2024-01-10)

• 主引用文献: Mpakali, A.,Saridakis, E.,Harlos, K.,Zhao, Y.,Papakyriakou, A.,Kokkala, P.,Georgiadis, D.,Stratikos, E.; Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.; J Immunol., 195:2842-2851, 2015; PubMed: 26259583; DOI: 10.4049/jimmunol.1501103

実験手法

X-RAY DIFFRACTION (3.31 Å)