4Z46
X-ray structure of the bis-platinum lysozyme adduct formed in the reaction between the protein and the two drugs Cisplatin and Oxaliplatin
Summary for 4Z46
Entry DOI | 10.2210/pdb4z46/pdb |
Descriptor | Lysozyme C, 1,2-ETHANEDIOL, NITRATE ION, ... (7 entities in total) |
Functional Keywords | cisplatin, oxaliplatin, protein platination, anticancer drugs, hydrolase |
Biological source | Gallus gallus (Chicken) |
Cellular location | Secreted: P00698 |
Total number of polymer chains | 1 |
Total formula weight | 15668.63 |
Authors | Merlino, A. (deposition date: 2015-04-01, release date: 2015-05-27, Last modification date: 2015-06-10) |
Primary citation | Marasco, D.,Messori, L.,Marzo, T.,Merlino, A. Oxaliplatin vs. cisplatin: competition experiments on their binding to lysozyme. Dalton Trans, 44:10392-10398, 2015 Cited by PubMed: 25974859DOI: 10.1039/c5dt01279a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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