4Z2Y

Crystal structure of methyltransferase CalO6

4Z2Y の概要

• エントリーDOI: 10.2210/pdb4z2y/pdb
• 分子名称: CalO6, MERCURY (II) ION (3 entities in total)
• 機能のキーワード: o-methyltransferase, calicheamicin, anticancer, antibiotic, transferase
• 由来する生物種: Micromonospora echinospora
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38713.56

構造登録者

Hou, C.,Garneau-Tsodikova, S.,Tsodikov, O.V. (登録日: 2015-03-30, 公開日: 2015-07-22, 最終更新日: 2024-03-06)

主引用文献

Tsodikov, O.V.,Hou, C.,Walsh, C.T.,Garneau-Tsodikova, S.
Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.
Bmc Struct.Biol., 15:13-13, 2015

PubMed Abstract: Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moiety at the C2 position of the orsellinic acid group of CAL.

PubMed: 26170207
DOI: 10.1186/s12900-015-0040-6

実験手法

X-RAY DIFFRACTION (3.4 Å)