4Z1L
Yeast 20S proteasome in complex with belactosin C derivative 3
Summary for 4Z1L
Entry DOI | 10.2210/pdb4z1l/pdb |
Related | 1RYP 3E47 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total) |
Functional Keywords | hydrolase, proteasome, inhibitor, binding analysis, lead structure motif, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 733423.33 |
Authors | Huber, E.M.,Groll, M. (deposition date: 2015-03-27, release date: 2015-05-27, Last modification date: 2024-01-10) |
Primary citation | Groll, M.,Korotkov, V.S.,Huber, E.M.,de Meijere, A.,Ludwig, A. A Minimal beta-Lactone Fragment for Selective beta 5c or beta 5i Proteasome Inhibitors. Angew.Chem.Int.Ed.Engl., 54:7810-7814, 2015 Cited by PubMed: 25973989DOI: 10.1002/anie.201502931 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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