4Z0L
The murine cyclooxygenase-2 complexed with a nido-dicarbaborate-containing indomethacin derivative
Summary for 4Z0L
Entry DOI | 10.2210/pdb4z0l/pdb |
Descriptor | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (8 entities in total) |
Functional Keywords | cyclooxygenase, indomethacin, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 4 |
Total formula weight | 279778.59 |
Authors | Xu, S.,Neumann, W.,Banerjee, S.,Hey-Hawkins, E.,Marnett, L.J. (deposition date: 2015-03-26, release date: 2015-06-10, Last modification date: 2023-09-27) |
Primary citation | Neumann, W.,Xu, S.,Sarosi, M.B.,Scholz, M.S.,Crews, B.C.,Ghebreselasie, K.,Banerjee, S.,Marnett, L.J.,Hey-Hawkins, E. nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2. Chemmedchem, 11:175-178, 2016 Cited by PubMed: 26088701DOI: 10.1002/cmdc.201500199 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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