4Z0L

The murine cyclooxygenase-2 complexed with a nido-dicarbaborate-containing indomethacin derivative

4Z0L の概要

• エントリーDOI: 10.2210/pdb4z0l/pdb
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (8 entities in total)
• 機能のキーワード: cyclooxygenase, indomethacin, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 279778.59

構造登録者

Xu, S.,Neumann, W.,Banerjee, S.,Hey-Hawkins, E.,Marnett, L.J. (登録日: 2015-03-26, 公開日: 2015-06-10, 最終更新日: 2023-09-27)

• 主引用文献: Neumann, W.,Xu, S.,Sarosi, M.B.,Scholz, M.S.,Crews, B.C.,Ghebreselasie, K.,Banerjee, S.,Marnett, L.J.,Hey-Hawkins, E.; nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.; Chemmedchem, 11:175-178, 2016; PubMed: 26088701; DOI: 10.1002/cmdc.201500199

実験手法

X-RAY DIFFRACTION (2.29 Å)