4Z07

Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP

4Z07 の概要

• エントリーDOI: 10.2210/pdb4z07/pdb
• 分子名称: cGMP-dependent protein kinase 1, CYCLIC GUANOSINE MONOPHOSPHATE, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: cgmp-binding domains, cgmp mediated dimeric interface, allosteric regulatory domain, serine-threonine kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 89930.95

構造登録者

Kim, J.J.,Reger, A.S.,Arold, S.T.,Kim, C. (登録日: 2015-03-25, 公開日: 2016-04-13, 最終更新日: 2023-09-27)

• 主引用文献: Kim, J.J.,Lorenz, R.,Arold, S.T.,Reger, A.S.,Sankaran, B.,Casteel, D.E.,Herberg, F.W.,Kim, C.; Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.; Structure, 24:710-720, 2016; PubMed: 27066748; DOI: 10.1016/j.str.2016.03.009

実験手法

X-RAY DIFFRACTION (2.5 Å)