4YWA

Structural Insight into Divalent Galactoside Binding to Pseudomonas aeruginosa lectin LecA

Summary for 4YWA

• Entry DOI: 10.2210/pdb4ywa/pdb
• Descriptor: PA-I galactophilic lectin, CALCIUM ION, (2R,3R,4S,5R,6R,2'R,3'R,4'S,5'R,6'R)-2,2'-([(2R,3R,4S,5S,6S)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2,5-diyl]bis{1H-1,2,3-triazole-1,4-diyl[(2S,3R,4S,5S,6S)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2,5-diyl]-1H-1,2,3-triazole-1,4-diylmethanediyloxy})bis[6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol], ... (4 entities in total)
• Functional Keywords: galactosides, lectins, sugar binding protein
• Biological source: Pseudomonas aeruginosa
• Cellular location: Cytoplasm: Q05097
• Total number of polymer chains: 4
• Total formula weight: 53426.80

Authors

Visini, R.,Jin, X.,Michaud, G.,Bergmann, M.,Gillon, E.,Imberty, A.,Stocker, A.,Darbre, T.,Pieters, R.,Reymond, J.-L. (deposition date: 2015-03-20, release date: 2015-09-09, Last modification date: 2024-01-10)

• Primary citation: Visini, R.,Jin, X.,Bergmann, M.,Michaud, G.,Pertici, F.,Fu, O.,Pukin, A.,Branson, T.R.,Thies-Weesie, D.M.,Kemmink, J.,Gillon, E.,Imberty, A.,Stocker, A.,Darbre, T.,Pieters, R.J.,Reymond, J.L.; Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA.; Acs Chem.Biol., 10:2455-2462, 2015; PubMed: 26295304; DOI: 10.1021/acschembio.5b00302

Experimental method

X-RAY DIFFRACTION (1.192 Å)