4YW5

Crystal Structure of Streptococcus pneumoniae NanC, complex with oseltamivir carboxylate

4YW5 の概要

• エントリーDOI: 10.2210/pdb4yw5/pdb
• 分子名称: Neuraminidase C, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: sialidase, neuraminidase, oseltamivir, cbm40, hydrolase
• 由来する生物種: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 149416.83

構造登録者

Owen, C.D.,Lukacik, P.,Potter, J.A.,Walsh, M.,Taylor, G.L. (登録日: 2015-03-20, 公開日: 2015-09-23, 最終更新日: 2024-01-10)

• 主引用文献: Owen, C.D.,Lukacik, P.,Potter, J.A.,Sleator, O.,Taylor, G.L.,Walsh, M.A.; Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.; J.Biol.Chem., 290:27736-27748, 2015; PubMed: 26370075; DOI: 10.1074/jbc.M115.673632

実験手法

X-RAY DIFFRACTION (2.3 Å)