4YVP
Crystal Structure of AKR1C1 complexed with glibenclamide
Summary for 4YVP
Entry DOI | 10.2210/pdb4yvp/pdb |
Related | 4YVV 4YVX |
Descriptor | Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... (4 entities in total) |
Functional Keywords | akr1c1 inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q04828 |
Total number of polymer chains | 2 |
Total formula weight | 76153.48 |
Authors | |
Primary citation | Zhao, Y.,Zheng, X.,Zhang, H.,Zhai, J.,Zhang, L.,Li, C.,Zeng, K.,Chen, Y.,Li, Q.,Hu, X. In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis Chem.Biol.Interact., 240:310-315, 2015 Cited by PubMed: 26362498DOI: 10.1016/j.cbi.2015.09.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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