4YUR

Crystal Structure of Plk4 Kinase Domain Bound to Centrinone

4YUR の概要

• エントリーDOI: 10.2210/pdb4yur/pdb
• 分子名称: Serine/threonine-protein kinase PLK4, 2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine (3 entities in total)
• 機能のキーワード: transferase, protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole: O00444
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32269.21

構造登録者

Shiau, A.K.,Motamedi, A. (登録日: 2015-03-19, 公開日: 2015-06-17, 最終更新日: 2023-09-27)

• 主引用文献: Wong, Y.L.,Anzola, J.V.,Davis, R.L.,Yoon, M.,Motamedi, A.,Kroll, A.,Seo, C.P.,Hsia, J.E.,Kim, S.K.,Mitchell, J.W.,Mitchell, B.J.,Desai, A.,Gahman, T.C.,Shiau, A.K.,Oegema, K.; Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.; Science, 348:1155-1160, 2015; PubMed: 25931445; DOI: 10.1126/science.aaa5111

実験手法

X-RAY DIFFRACTION (2.65 Å)