4YT1

Human PPAR Gamma Ligand Binding Domain in complex with a Gammma Selective Synthetic Partial Agonist MEKT76

4YT1 の概要

• エントリーDOI: 10.2210/pdb4yt1/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, N-(benzylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide (3 entities in total)
• 機能のキーワード: nuclear receptor, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65605.93

構造登録者

Oyama, T.,Ohashi, M.,Miyachi, H.,Kusunoki, M. (登録日: 2015-03-17, 公開日: 2016-03-02, 最終更新日: 2023-11-08)

• 主引用文献: Ohashi, M.,Gamo, K.,Oyama, T.,Miyachi, H.; Peroxisome proliferator-activated receptor gamma (PPAR gamma ) has multiple binding points that accommodate ligands in various conformations: Structurally similar PPAR gamma partial agonists bind to PPAR gamma LBD in different conformations; Bioorg.Med.Chem.Lett., 25:2758-2762, 2015; PubMed: 26025876; DOI: 10.1016/j.bmcl.2015.05.025

実験手法

X-RAY DIFFRACTION (2.2 Å)