4YSX

Crystal structure of Mitochondrial rhodoquinol-fumarate reductase from Ascaris suum with the specific inhibitor NN23

Summary for 4YSX

• Entry DOI: 10.2210/pdb4ysx/pdb
• Related: 3AE5 3AE7 3AE8 3AE9 3VR8 3VRB 4YSY 4YSZ 4YT0 4YTM 4YTN 4YTP 4YXD
• Descriptor: Succinate dehydrogenase flavoprotein, N-(4-tert-butylbenzyl)-2-(trifluoromethyl)benzamide, PROTOPORPHYRIN IX CONTAINING FE, ... (13 entities in total)
• Functional Keywords: rhodoquinol-fumarate reductase, complex ii, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Ascaris suum (Pig roundworm); More
• Cellular location: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side : U1LRQ3 O44074; Mitochondrion inner membrane ; Multi-pass membrane protein : P92507
• Total number of polymer chains: 8
• Total formula weight: 289243.76

Authors

Harada, S.,Shiba, T.,Sato, D.,Yamamoto, A.,Nagahama, M.,Yone, A.,Inaoka, D.K.,Sakamoto, K.,Inoue, M.,Honma, T.,Kita, K. (deposition date: 2015-03-17, release date: 2015-08-05, Last modification date: 2023-11-08)

• Primary citation: Inaoka, D.K.,Shiba, T.,Sato, D.,Balogun, E.O.,Sasaki, T.,Nagahama, M.,Oda, M.,Matsuoka, S.,Ohmori, J.,Honma, T.,Inoue, M.,Kita, K.,Harada, S.; Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria; Int J Mol Sci, 16:15287-15308, 2015; PubMed: 26198225; DOI: 10.3390/ijms160715287

Experimental method

X-RAY DIFFRACTION (2.25 Å)