4YRD

Crystal structure of CapF with inhibitor 3-isopropenyl-tropolone

Summary for 4YRD

• Entry DOI: 10.2210/pdb4yrd/pdb
• Descriptor: Capsular polysaccharide synthesis enzyme Cap5F, ZINC ION, 2-hydroxy-3-(prop-1-en-2-yl)cyclohepta-2,4,6-trien-1-one, ... (4 entities in total)
• Functional Keywords: capf cupin capsular polysaccharide staphylococcus aureus, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Staphylococcus aureus (strain Mu50 / ATCC 700699)
• Total number of polymer chains: 2
• Total formula weight: 82379.43

Authors

Nakano, K.,Chigira, T.,Miyafusa, T.,Nagatoishi, S.,Caaveiro, J.M.M.,Tsumoto, K. (deposition date: 2015-03-15, release date: 2015-10-21, Last modification date: 2023-11-08)

• Primary citation: Nakano, K.,Chigira, T.,Miyafusa, T.,Nagatoishi, S.,Caaveiro, J.M.,Tsumoto, K.; Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus.; Sci Rep, 5:15337-15337, 2015; PubMed: 26471247; DOI: 10.1038/srep15337

Experimental method

X-RAY DIFFRACTION (2.44 Å)