4YO8

Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)(hexyl)amino)methanol

Summary for 4YO8

• Entry DOI: 10.2210/pdb4yo8/pdb
• Related: 4FFS 4WKN 4WKO 4WKP 4YNB
• Descriptor: Aminodeoxyfutalosine nucleosidase, {[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](hexyl)amino}methanol, ZINC ION, ... (4 entities in total)
• Functional Keywords: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Helicobacter pylori
• Total number of polymer chains: 2
• Total formula weight: 54393.89

Authors

Cameron, S.A.,Wang, S.,Almo, S.C.,Schramm, V.L. (deposition date: 2015-03-11, release date: 2015-11-25, Last modification date: 2023-09-27)

• Primary citation: Wang, S.,Cameron, S.A.,Clinch, K.,Evans, G.B.,Wu, Z.,Schramm, V.L.,Tyler, P.C.; New Antibiotic Candidates against Helicobacter pylori.; J.Am.Chem.Soc., 137:14275-14280, 2015; PubMed: 26494017; DOI: 10.1021/jacs.5b06110

Experimental method

X-RAY DIFFRACTION (2.1 Å)