4YNE

(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors

Summary for 4YNE

• Entry DOI: 10.2210/pdb4yne/pdb
• Descriptor: High affinity nerve growth factor receptor, 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine, SULFATE ION, ... (5 entities in total)
• Functional Keywords: kinase, trk, inhibitor, oncology, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P04629
• Total number of polymer chains: 1
• Total formula weight: 35193.42

Authors

Kreusch, A.,Rucker, P.,Molteni, V.,Loren, J. (deposition date: 2015-03-09, release date: 2015-06-03, Last modification date: 2023-09-27)

• Primary citation: Choi, H.S.,Rucker, P.V.,Wang, Z.,Fan, Y.,Albaugh, P.,Chopiuk, G.,Gessier, F.,Sun, F.,Adrian, F.,Liu, G.,Hood, T.,Li, N.,Jia, Y.,Che, J.,McCormack, S.,Li, A.,Li, J.,Steffy, A.,Culazzo, A.,Tompkins, C.,Phung, V.,Kreusch, A.,Lu, M.,Hu, B.,Chaudhary, A.,Prashad, M.,Tuntland, T.,Liu, B.,Harris, J.,Seidel, H.M.,Loren, J.,Molteni, V.; (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.; Acs Med.Chem.Lett., 6:562-567, 2015; PubMed: 26005534; DOI: 10.1021/acsmedchemlett.5b00050

Experimental method

X-RAY DIFFRACTION (2.0229 Å)