4YMB

Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG10111

4YMB の概要

• エントリーDOI: 10.2210/pdb4ymb/pdb
• 関連するPDBエントリー: 4E0X
• 分子名称: Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, (3R,4S)-3-(3-carboxyphenyl)-4-propyl-L-proline, ACETATE ION, ... (7 entities in total)
• 機能のキーワード: ionotropic glutamate receptor, kainate receptor gluk1, ligand-binding domain, antagonist, signaling protein, fusion protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P22756
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59317.71

構造登録者

Moller, C.,Tapken, D.,Kastrup, J.S.,Frydenvang, K. (登録日: 2015-03-06, 公開日: 2015-08-05, 最終更新日: 2024-01-10)

• 主引用文献: Krogsgaard-Larsen, N.,Storgaard, M.,Moller, C.,Demmer, C.S.,Hansen, J.,Han, L.,Monrad, R.N.,Nielsen, B.,Tapken, D.,Pickering, D.S.,Kastrup, J.S.,Frydenvang, K.,Bunch, L.; Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid.; J.Med.Chem., 58:6131-6150, 2015; PubMed: 26200741; DOI: 10.1021/acs.jmedchem.5b00750

実験手法

X-RAY DIFFRACTION (1.93 Å)