4YM9

Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the novel inhibitor JM102

4YM9 の概要

• エントリーDOI: 10.2210/pdb4ym9/pdb
• 分子名称: Chymotrypsin-like elastase family member 1, 2-ethyl-2-(hydroxymethyl)-N-(6-methylpyridin-3-yl)butanamide, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: porcine pancreatic elastase, inhibitor, hydrolase
• 由来する生物種: Sus scrofa (Pig)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27055.95

構造登録者

Hofbauer, S.,Brito, J.A.,Mulchande, J.,Nogly, P.,Pessanha, M.,Moreira, R.,Archer, M. (登録日: 2015-03-06, 公開日: 2016-06-29, 最終更新日: 2024-01-10)

• 主引用文献: Ruivo, E.F.,Goncalves, L.M.,Carvalho, L.A.,Guedes, R.C.,Hofbauer, S.,Brito, J.A.,Archer, M.,Moreira, R.,Lucas, S.D.; Clickable 4-Oxo-beta-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes.; ChemMedChem, 11:2037-2042, 2016; PubMed: 27465595; DOI: 10.1002/cmdc.201600258

実験手法

X-RAY DIFFRACTION (1.8 Å)