4YLJ

Crystal structure of DYRK1A in complex with 10-Iodo-substituted 11H-indolo[3,2-c]quinoline-6-carboxylic acid inhibitor 5j

4YLJ の概要

• エントリーDOI: 10.2210/pdb4ylj/pdb
• 関連するPDBエントリー: 4YLK 4YLL
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, TETRAETHYLENE GLYCOL, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: halogen, inhibitor, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q13627
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 172198.99

構造登録者

Chaikuad, A.,Falke, H.,Nowak, R.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2015-03-05, 公開日: 2015-03-25, 最終更新日: 2023-11-15)

• 主引用文献: Falke, H.,Chaikuad, A.,Becker, A.,Loaec, N.,Lozach, O.,Abu Jhaisha, S.,Becker, W.,Jones, P.G.,Preu, L.,Baumann, K.,Knapp, S.,Meijer, L.,Kunick, C.; 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A.; J.Med.Chem., 58:3131-3143, 2015; PubMed: 25730262; DOI: 10.1021/jm501994d

実験手法

X-RAY DIFFRACTION (2.58 Å)