4YLJ
Crystal structure of DYRK1A in complex with 10-Iodo-substituted 11H-indolo[3,2-c]quinoline-6-carboxylic acid inhibitor 5j
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 361 | 42081.5 | 4 | UniProt (Q13627) Pfam (PF00069) In PDB | Homo sapiens (Human) | Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, hMNB |
| 2 | A, B, C, D | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 7 | Chemie (PG4) | |||
| 3 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 4 | A, B, C, D | 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid | non-polymer | 388.2 | 4 | Chemie (4E1) | |||
| 5 | water | water | 18.0 | 247 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 127 - 485 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Ser 125 | - | expression tag |
| Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 168326.1 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 3872.8 | |
| All* | Total formula weight | 172199.0 |
