4YHQ

Crystal structure of multidrug resistant clinical isolate PR20 with GRL-5010A

4YHQ の概要

• エントリーDOI: 10.2210/pdb4yhq/pdb
• 分子名称: Protease, (3R,3aS,6aS)-4,4-difluorohexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, YTTRIUM ION, ... (7 entities in total)
• 機能のキーワード: hiv protease, mutant, drug resistant, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype (HIV-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22856.80

構造登録者

Agniswamy, J.,Weber, I.T. (登録日: 2015-02-27, 公開日: 2015-06-10, 最終更新日: 2023-09-27)

• 主引用文献: Agniswamy, J.,Louis, J.M.,Shen, C.H.,Yashchuk, S.,Ghosh, A.K.,Weber, I.T.; Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20.; J.Med.Chem., 58:5088-5095, 2015; PubMed: 26010498; DOI: 10.1021/acs.jmedchem.5b00474

実験手法

X-RAY DIFFRACTION (1.3 Å)