4YFK
Escherichia coli RNA polymerase in complex with squaramide compound 8.
Summary for 4YFK
Entry DOI | 10.2210/pdb4yfk/pdb |
Related | 4YFN 4YFX |
Descriptor | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total) |
Functional Keywords | switch region, squaramide, transcription-inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Escherichia coli O139:H28 (strain E24377A / ETEC) More |
Total number of polymer chains | 12 |
Total formula weight | 921059.50 |
Authors | Molodtsov, V.,Fleming, P.R.,Eyermann, C.J.,Ferguson, A.D.,Foulk, M.A.,McKinney, D.C.,Masse, C.E.,Buurman, E.T.,Murakami, K.S. (deposition date: 2015-02-25, release date: 2015-03-11, Last modification date: 2023-09-27) |
Primary citation | Molodtsov, V.,Fleming, P.R.,Eyermann, C.J.,Ferguson, A.D.,Foulk, M.A.,McKinney, D.C.,Masse, C.E.,Buurman, E.T.,Murakami, K.S. X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58:3156-3171, 2015 Cited by PubMed: 25798859DOI: 10.1021/acs.jmedchem.5b00050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.571 Å) |
Structure validation
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