4YFK

Escherichia coli RNA polymerase in complex with squaramide compound 8.

4YFK の概要

• エントリーDOI: 10.2210/pdb4yfk/pdb
• 関連するPDBエントリー: 4YFN 4YFX
• 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total)
• 機能のキーワード: switch region, squaramide, transcription-inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Escherichia coli O139:H28 (strain E24377A / ETEC); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 921059.50

構造登録者

Molodtsov, V.,Fleming, P.R.,Eyermann, C.J.,Ferguson, A.D.,Foulk, M.A.,McKinney, D.C.,Masse, C.E.,Buurman, E.T.,Murakami, K.S. (登録日: 2015-02-25, 公開日: 2015-03-11, 最終更新日: 2023-09-27)

• 主引用文献: Molodtsov, V.,Fleming, P.R.,Eyermann, C.J.,Ferguson, A.D.,Foulk, M.A.,McKinney, D.C.,Masse, C.E.,Buurman, E.T.,Murakami, K.S.; X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.; J.Med.Chem., 58:3156-3171, 2015; PubMed: 25798859; DOI: 10.1021/acs.jmedchem.5b00050

実験手法

X-RAY DIFFRACTION (3.571 Å)