4YDM
High resolution crystal structure of human transthyretin bound to ligand and conjugates of 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate
Summary for 4YDM
Entry DOI | 10.2210/pdb4ydm/pdb |
Related | 4YDN |
Descriptor | Transthyretin, 2,6-dichloro-4-[5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol (3 entities in total) |
Functional Keywords | transthyretin, hormone transport protein, thyroxine, retinol, transport protein |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28359.10 |
Authors | Connelly, S.,Bradbury, N.C. (deposition date: 2015-02-22, release date: 2015-07-15, Last modification date: 2023-09-27) |
Primary citation | Baranczak, A.,Liu, Y.,Connelly, S.,Du, W.G.,Greiner, E.R.,Genereux, J.C.,Wiseman, R.L.,Eisele, Y.S.,Bradbury, N.C.,Dong, J.,Noodleman, L.,Sharpless, K.B.,Wilson, I.A.,Encalada, S.E.,Kelly, J.W. A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. J.Am.Chem.Soc., 137:7404-7414, 2015 Cited by PubMed: 26051248DOI: 10.1021/jacs.5b03042 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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