4YD0
Influenza polymerase basic protein 2 (PB2) bound to an azaindole-tetrazole inhibitor
Summary for 4YD0
Entry DOI | 10.2210/pdb4yd0/pdb |
Descriptor | Polymerase basic protein 2, 2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-[(1R,2S,3S,4R)-3-(1H-tetrazol-5-yl)bicyclo[2.2.2]oct-2-yl]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | small-molecule drug, inhibitor, flu, m7-gtp pocket, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Influenza A virus |
Cellular location | Virion: Q30NP1 |
Total number of polymer chains | 1 |
Total formula weight | 19614.20 |
Authors | Jacobs, M.D. (deposition date: 2015-02-20, release date: 2015-04-15, Last modification date: 2024-02-28) |
Primary citation | Boyd, M.J.,Bandarage, U.K.,Bennett, H.,Byrn, R.R.,Davies, I.,Gu, W.,Jacobs, M.,Ledeboer, M.W.,Ledford, B.,Leeman, J.R.,Perola, E.,Wang, T.,Bennani, Y.,Clark, M.P.,Charifson, P.S. Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg.Med.Chem.Lett., 25:1990-1994, 2015 Cited by PubMed: 25827523DOI: 10.1016/j.bmcl.2015.03.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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