4YBK
C-Helix-Out Dasatinib Analog Crystallized with c-Src Kinase
Summary for 4YBK
Entry DOI | 10.2210/pdb4ybk/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide (3 entities in total) |
Functional Keywords | protein kinase, c-helix-out, transferase |
Biological source | Gallus gallus (Chicken) |
Cellular location | Cell membrane : P00523 |
Total number of polymer chains | 1 |
Total formula weight | 33258.27 |
Authors | Kwarcinski, F.E.,Brandvold, K.B.,Johnson, T.K.,Phadke, S.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B. (deposition date: 2015-02-18, release date: 2016-03-02, Last modification date: 2023-09-27) |
Primary citation | Kwarcinski, F.E.,Brandvold, K.R.,Phadke, S.,Beleh, O.M.,Johnson, T.K.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B. Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. Acs Chem.Biol., 11:1296-1304, 2016 Cited by PubMed: 26895387DOI: 10.1021/acschembio.5b01018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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