4Y9G
Crystal structure of V30M mutated transthyretin in complex with 3-isomangostin
Summary for 4Y9G
| Entry DOI | 10.2210/pdb4y9g/pdb |
| Related | 4PWE 4Y9B 4Y9C 4Y9E 4Y9F |
| Descriptor | Transthyretin, 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one (3 entities in total) |
| Functional Keywords | transthyretin, inhibitor, natural product, mangostin, transporter, amyloidosis, kinetic stabilizer, transport protein-inhibitor complex, transport protein/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 35506.08 |
| Authors | Yokoyama, T.,Mizuguchi, M. (deposition date: 2015-02-17, release date: 2015-09-09, Last modification date: 2023-11-08) |
| Primary citation | Yokoyama, T.,Ueda, M.,Ando, Y.,Mizuguchi, M. Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor Sci Rep, 5:13570-13570, 2015 Cited by PubMed: 26310724DOI: 10.1038/srep13570 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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