4Y9G

Crystal structure of V30M mutated transthyretin in complex with 3-isomangostin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transthyretin	polymer	159	17342.6	2	UniProt (P02766) Pfam (PF00576)	Homo sapiens (Human)	ATTR,Prealbumin,TBPA
2	C, D (A, B)	5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one	non-polymer		410.5	2	Chemie (MKU)
3	E, F (A, B)	water	water		18.0	87	Chemie (HOH)

Sequence modifications

A, B: -19 - 127 (UniProt: P02766)

PDB	External Database	Details
Met -31	-	expression tag
Arg -30	-	expression tag
Gly -29	-	expression tag
Ser -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Met 30	Val 50	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34685.2
Non-Polymers*	Number of molecules	2
	Total formula weight	820.9
All*	Total formula weight	35506.1

*Water molecules are not included.