4Y95

Crystal structure of the kinase domain of Bruton's tyrosine kinase with mutations in the activation loop

4Y95 の概要

• エントリーDOI: 10.2210/pdb4y95/pdb
• 関連するPDBエントリー: 4Y93 4Y94
• 分子名称: Non-specific protein-tyrosine kinase, 4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: btk, kinase domain, transferase
• 由来する生物種: Bos taurus (Bovine)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128177.75

構造登録者

Wang, Q.,Rosen, C.E.,Kuriyan, J. (登録日: 2015-02-16, 公開日: 2015-03-18, 最終更新日: 2024-02-28)

• 主引用文献: Wang, Q.,Vogan, E.M.,Nocka, L.M.,Rosen, C.E.,Zorn, J.A.,Harrison, S.C.,Kuriyan, J.; Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.; Elife, 4:-, 2015; PubMed: 25699547; DOI: 10.7554/eLife.06074

実験手法

X-RAY DIFFRACTION (1.599 Å)