4Y8D

Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor

4Y8D の概要

• エントリーDOI: 10.2210/pdb4y8d/pdb
• 分子名称: Cyclin-G-associated kinase, nanobody, 2-methoxy-4-[3-(morpholin-4-yl)[1,2]thiazolo[4,3-b]pyridin-6-yl]aniline, ... (5 entities in total)
• 機能のキーワード: transferase, kinase, nanobody, inhibitor, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm, perinuclear region : O14976
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 107533.29

構造登録者

Chaikuad, A.,Heroven, C.,Nowak, R.,De Jonghe, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2015-02-16, 公開日: 2015-04-08, 最終更新日: 2024-01-10)

• 主引用文献: Kovackova, S.,Chang, L.,Bekerman, E.,Neveu, G.,Barouch-Bentov, R.,Chaikuad, A.,Heroven, C.,Sala, M.,De Jonghe, S.,Knapp, S.,Einav, S.,Herdewijn, P.; Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.; J.Med.Chem., 58:3393-3410, 2015; PubMed: 25822739; DOI: 10.1021/jm501759m

実験手法

X-RAY DIFFRACTION (2.1 Å)