4Y87
Crystal structure of phosphodiesterase 9 in complex with (R)-C33 (6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one)
Summary for 4Y87
Entry DOI | 10.2210/pdb4y87/pdb |
Related | 4Y86 |
Descriptor | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, 6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, ZINC ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase 9a, inhibitor selectivity pocket, pharmacokinetics, enantiomeric differentiation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 124473.26 |
Authors | Huang, M. (deposition date: 2015-02-16, release date: 2015-09-16, Last modification date: 2024-02-28) |
Primary citation | Huang, M.,Shao, Y.,Hou, J.,Cui, W.,Liang, B.,Huang, Y.,Li, Z.,Wu, Y.,Zhu, X.,Liu, P.,Wan, Y.,Ke, H.,Luo, H.B. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol.Pharmacol., 88:836-845, 2015 Cited by PubMed: 26316540DOI: 10.1124/mol.115.099747 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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