4Y85
Crystal structure of COT kinase domain in complex with 5-(5-(1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine
Summary for 4Y85
Entry DOI | 10.2210/pdb4y85/pdb |
Related | 4Y83 |
Descriptor | Mitogen-activated protein kinase kinase kinase 8, 5-[5-(1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1,3,4-oxadiazol-2-amine (3 entities in total) |
Functional Keywords | cot, tpl-2, map3k8, kinase, inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 113854.55 |
Authors | Gutmann, S.,Hinniger, A. (deposition date: 2015-02-16, release date: 2015-05-06, Last modification date: 2024-05-08) |
Primary citation | Gutmann, S.,Hinniger, A.,Fendrich, G.,Druckes, P.,Antz, S.,Mattes, H.,Mobitz, H.,Ofner, S.,Schmiedeberg, N.,Stojanovic, A.,Rieffel, S.,Strauss, A.,Troxler, T.,Glatthar, R.,Sparrer, H. The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold. J.Biol.Chem., 290:15210-15218, 2015 Cited by PubMed: 25918157DOI: 10.1074/jbc.M115.648097 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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