4Y83

Crystal structure of COT kinase domain in complex with 5-(2-amino-5-(quinolin-3-yl)pyridin-3-yl)-1,3,4-oxadiazole-2(3H)-thione

4Y83 の概要

• エントリーDOI: 10.2210/pdb4y83/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase 8, 5-[2-amino-5-(quinolin-3-yl)pyridin-3-yl]-1,3,4-oxadiazole-2(3H)-thione (3 entities in total)
• 機能のキーワード: cot, tpl-2, map3k8, kinase, inhibitor, complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 113869.67

構造登録者

Gutmann, S.,Hinniger, A. (登録日: 2015-02-16, 公開日: 2015-05-06, 最終更新日: 2024-05-08)

• 主引用文献: Gutmann, S.,Hinniger, A.,Fendrich, G.,Druckes, P.,Antz, S.,Mattes, H.,Mobitz, H.,Ofner, S.,Schmiedeberg, N.,Stojanovic, A.,Rieffel, S.,Strauss, A.,Troxler, T.,Glatthar, R.,Sparrer, H.; The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.; J.Biol.Chem., 290:15210-15218, 2015; PubMed: 25918157; DOI: 10.1074/jbc.M115.648097

実験手法

X-RAY DIFFRACTION (2.89 Å)