4Y76

Factor Xa complex with GTC000401

Summary for 4Y76

• Entry DOI: 10.2210/pdb4y76/pdb
• Descriptor: Coagulation factor X, CALCIUM ION, N~2~-[(6-chloronaphthalen-2-yl)sulfonyl]-N~2~-{(3S)-1-[(2S)-1-(4-methyl-1,4-diazepan-1-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl}glycinamide, ... (5 entities in total)
• Functional Keywords: hydrolase, inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 44351.54

Authors

Convery, M.A.,Young, R.J.,Senger, S.,Hamblin, J.N.,Chan, C.,Toomey, J.R.,Watson, N.S. (deposition date: 2015-02-13, release date: 2015-09-30, Last modification date: 2024-01-10)

• Primary citation: Chan, C.,Borthwick, A.D.,Brown, D.,Burns-Kurtis, C.L.,Campbell, M.,Chaudry, L.,Chung, C.W.,Convery, M.A.,Hamblin, J.N.,Johnstone, L.,Kelly, H.A.,Kleanthous, S.,Patikis, A.,Patel, C.,Pateman, A.J.,Senger, S.,Shah, G.P.,Toomey, J.R.,Watson, N.S.,Weston, H.E.,Whitworth, C.,Young, R.J.,Zhou, P.; Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides.; J. Med. Chem., 50:1546-1557, 2007; PubMed: 17338508; DOI: 10.1021/jm060870c

Experimental method

X-RAY DIFFRACTION (2 Å)