4Y6A

Yeast 20S proteasome beta2-H114D mutant in complex with Ac-PAD-ep

Summary for 4Y6A

Related1RYP
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (18 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
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Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains30
Total molecular weight731988.55
Authors
Huber, E.M.,Groll, M. (deposition date: 2015-02-12, release date: 2015-06-17, Last modification date: 2016-02-03)
Primary citation
Huber, E.M.,de Bruin, G.,Heinemeyer, W.,Paniagua Soriano, G.,Overkleeft, H.S.,Groll, M.
Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors.
J.Am.Chem.Soc., 137:7835-7842, 2015
PubMed: 26020686 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.5b03688
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23610.3%3.3%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution