4Y62

AAGlyB in complex with amino-acid analogues

Summary for 4Y62

• Entry DOI: 10.2210/pdb4y62/pdb
• Descriptor: Histo-blood group ABO system transferase, octyl 2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-galactopyranoside, 5'-deoxy-5'-{[(2R)-3-hydroxy-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoyl]amino}uridine, ... (4 entities in total)
• Functional Keywords: aaglyb, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• Total number of polymer chains: 1
• Total formula weight: 41843.63

Authors

Wang, S.,Cuesta-Seijo, J.A.,Striebeck, A.,Lafont, D.,Palcic, M.M.,Vidal, S. (deposition date: 2015-02-12, release date: 2015-09-16, Last modification date: 2024-01-10)

• Primary citation: Wang, S.,Cuesta-Seijo, J.A.,Striebeck, A.,Lafont, D.,Palcic, M.M.,Vidal, S.; Design of Glycosyltransferase Inhibitors: Serine Analogues as Pyrophosphate Surrogates?; Chempluschem, 80:1525-1532, 2015; DOI: 10.1002/cplu.201500282

Experimental method

X-RAY DIFFRACTION (1.6 Å)