4Y5D

CRYSTAL STRUCTURE OF ALiS2-STREPTAVIDIN COMPLEX

Summary for 4Y5D

Related4Y59
DescriptorStreptavidin, methyl 3-(4-oxo-4,5-dihydrofuro[3,2-c]pyridin-2-yl)benzoate, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, ... (6 entities in total)
Functional Keywordsbiotin-binding protein, inhibitor
Biological sourceStreptomyces avidinii
Cellular locationSecreted P22629
Total number of polymer chains4
Total molecular weight53492.95
Authors
Sugiyama, S.,Terai, T.,Kohno, M.,Ishida, H.,Nagano, T. (deposition date: 2015-02-11, release date: 2015-09-23, Last modification date: 2015-12-16)
Primary citation
Terai, T.,Kohno, M.,Boncompain, G.,Sugiyama, S.,Saito, N.,Fujikake, R.,Ueno, T.,Komatsu, T.,Hanaoka, K.,Okabe, T.,Urano, Y.,Perez, F.,Nagano, T.
Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport
J.Am.Chem.Soc., 137:10464-10467, 2015
PubMed: 26261872 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.5b05672
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.174110.4%2.8%5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution