4Y40

Structure of Vaspin mutant D305C V383C

Summary for 4Y40

• Entry DOI: 10.2210/pdb4y40/pdb
• Related: 4IF8 4Y3K
• Descriptor: Serpin A12, 1,2-ETHANEDIOL, SULFATE ION, ... (4 entities in total)
• Functional Keywords: serpin, adipokine, exosite, signaling protein, hydrolase inhibitor, hydrloase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: Q8IW75
• Total number of polymer chains: 2
• Total formula weight: 95702.40

Authors

Pippel, J.,Strater, N.,Ulbricht, D.,Schultz, S.,Meier, R.,Heiker, J.T. (deposition date: 2015-02-10, release date: 2015-08-12, Last modification date: 2024-01-10)

• Primary citation: Ulbricht, D.,Pippel, J.,Schultz, S.,Meier, R.,Strater, N.,Heiker, J.T.; A unique serpin P1' glutamate and a conserved beta-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin).; Biochem.J., 470:357-367, 2015; PubMed: 26199422; DOI: 10.1042/BJ20150643

Experimental method

X-RAY DIFFRACTION (2.2 Å)