4Y2B

Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A

Summary for 4Y2B

Entry DOI	10.2210/pdb4y2b/pdb
Descriptor	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, pde7a, camp, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform PDE7A1: Cytoplasm, cytosol. Isoform PDE7A2: Cytoplasm: Q13946
Total number of polymer chains	1
Total formula weight	44953.31
Authors	Endo, Y.,Kawai, K.,Asano, T.,Amano, S.,Asanuma, Y.,Sawada, K.,Onodera, Y.,Ueo, N.,Takahashi, N.,Sonoda, Y.,Kamei, N.,Irie, T. (deposition date: 2015-02-09, release date: 2015-04-08, Last modification date: 2023-11-08)
Primary citation	Endo, Y.,Kawai, K.,Asano, T.,Amano, S.,Asanuma, Y.,Sawada, K.,Onodera, Y.,Ueo, N.,Takahashi, N.,Sonoda, Y.,Kamei, N.,Irie, T. 2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy Bioorg.Med.Chem.Lett., 25:1910-1914, 2015 Cited by PubMed: 25866242 DOI: 10.1016/j.bmcl.2015.03.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation