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4Y29

Identification of a novel PPARg ligand that regulates metabolism

4Y29 の概要
エントリーDOI10.2210/pdb4y29/pdb
分子名称Peroxisome proliferator-activated receptor gamma, Peptide from Nuclear receptor coactivator 1, 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, ... (4 entities in total)
機能のキーワードaf-2 helix, ligand binding pocket, three-layer helical sandwich, transcription regulator pparg, nr1c3, peroxisome proliferator-activated receptor gamma, nhr, nuclear receptor, coactivator, transcription factor, dna binding protein-transcription complex, dna binding protein/transcription
由来する生物種Homo sapiens (Human)
詳細
細胞内の位置Nucleus: P37231 Q15788
タンパク質・核酸の鎖数2
化学式量合計32226.49
構造登録者
Wang, R.,Li, Y. (登録日: 2015-02-09, 公開日: 2015-09-09, 最終更新日: 2023-11-08)
主引用文献Zheng, W.L.,Qiu, L.,Wang, R.,Feng, X.H.,Han, Y.P.,Zhu, Y.L.,Chen, D.Z.,Liu, Y.J.,Jin, L.H.,Li, Y.
Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency.
Sci Rep, 5:12222-12222, 2015
Cited by
PubMed: 26183621
DOI: 10.1038/srep12222
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.98 Å)
構造検証レポート
Validation report summary of 4y29
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-09-18に公開中

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