4Y29

Identification of a novel PPARg ligand that regulates metabolism

4Y29 の概要

• エントリーDOI: 10.2210/pdb4y29/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, Peptide from Nuclear receptor coactivator 1, 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, ... (4 entities in total)
• 機能のキーワード: af-2 helix, ligand binding pocket, three-layer helical sandwich, transcription regulator pparg, nr1c3, peroxisome proliferator-activated receptor gamma, nhr, nuclear receptor, coactivator, transcription factor, dna binding protein-transcription complex, dna binding protein/transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: P37231 Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32226.49

構造登録者

Wang, R.,Li, Y. (登録日: 2015-02-09, 公開日: 2015-09-09, 最終更新日: 2023-11-08)

• 主引用文献: Zheng, W.L.,Qiu, L.,Wang, R.,Feng, X.H.,Han, Y.P.,Zhu, Y.L.,Chen, D.Z.,Liu, Y.J.,Jin, L.H.,Li, Y.; Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency.; Sci Rep, 5:12222-12222, 2015; PubMed: 26183621; DOI: 10.1038/srep12222

実験手法

X-RAY DIFFRACTION (1.98 Å)