4Y0D

Gamma-aminobutyric acid aminotransferase inactivated by (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115)

Summary for 4Y0D

• Entry DOI: 10.2210/pdb4y0d/pdb
• Related: 4Y0H
• Descriptor: 4-aminobutyrate aminotransferase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, (1S)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopent-3-ene-1,3-dicarboxylic acid, ... (5 entities in total)
• Functional Keywords: gaba-at, inactivator, transferase
• Biological source: Sus scrofa (Pig)
• Cellular location: Mitochondrion matrix: P80147
• Total number of polymer chains: 4
• Total formula weight: 211816.80

Authors

Rui, W.,Ruslan, S.,Hyunbeom, L.,Emma, H.D.,Jose, I.J.,Neil, K.,Richard, B.S.,Dali, L. (deposition date: 2015-02-05, release date: 2015-02-25, Last modification date: 2024-02-28)

• Primary citation: Hyunbeom, L.,Emma, H.D.,Rui, W.,Ruslan, S.,Jose, I.J.,Dali, L.,Neil, K.,Richard, B.S.; Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115); J. Am. Chem. Soc., 2015; PubMed: 25616005; DOI: 10.1021/ja512299n

Experimental method

X-RAY DIFFRACTION (2.19 Å)