4Y00
Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA
Summary for 4Y00
Entry DOI | 10.2210/pdb4y00/pdb |
Related | 4Y0F |
Descriptor | TAR DNA-binding protein 43, DNA (5'-D(P*TP*TP*GP*AP*GP*CP*GP*T)-3') (3 entities in total) |
Functional Keywords | rna recognition motif 1 complex, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q13148 |
Total number of polymer chains | 8 |
Total formula weight | 60390.94 |
Authors | Chiang, C.H.,Kuo, P.H.,Yang, W.Z.,Yuan, H.S. (deposition date: 2015-02-05, release date: 2016-02-10, Last modification date: 2023-11-08) |
Primary citation | Chiang, C.H.,Grauffel, C.,Wu, L.S.,Kuo, P.H.,Doudeva, L.G.,Lim, C.,Shen, C.K.,Yuan, H.S. Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation Sci Rep, 6:21581-21581, 2016 Cited by PubMed: 26883171DOI: 10.1038/srep21581 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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