4XZI
Crystal structure of human Aldose Reductase complexed with NADP+ and JF0049
Summary for 4XZI
Entry DOI | 10.2210/pdb4xzi/pdb |
Related | 1US0 |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,4-dioxo-3-(2,3,4,5-tetrabromo-6-methoxybenzyl)-3,4-dihydropyrimidin-1(2H)-yl]acetic acid, ... (4 entities in total) |
Functional Keywords | tim barrel, aldose reductase, oxidoreductase, diabetes, halogenated compound, cytosolic |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37247.60 |
Authors | Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Dominguez, M.,de Lera, A.R.,Farres, J.,Pares, X.,Podjarny, A. (deposition date: 2015-02-04, release date: 2015-11-18, Last modification date: 2024-01-10) |
Primary citation | Ruiz, F.X.,Cousido-Siah, A.,Porte, S.,Dominguez, M.,Crespo, I.,Rechlin, C.,Mitschler, A.,de Lera, A.R.,Martin, M.J.,de la Fuente, J.A.,Klebe, G.,Pares, X.,Farres, J.,Podjarny, A. Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10:1989-2003, 2015 Cited by PubMed: 26549844DOI: 10.1002/cmdc.201500393 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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