4XYF

Crystal structure of c-Met in complex with (S)-5-(8-fluoro-3-(1-(3-(2-methoxyethoxy)quinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole

4XYF の概要

• エントリーDOI: 10.2210/pdb4xyf/pdb
• 関連するPDBエントリー: 4XMO
• 分子名称: Hepatocyte growth factor receptor, 6-{(1S)-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)quinoline (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, inhibitor, complex, intracellular catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35663.18

構造登録者

Whittington, D.A.,Long, A.M. (登録日: 2015-02-02, 公開日: 2015-03-11, 最終更新日: 2023-09-27)

• 主引用文献: Peterson, E.A.,Teffera, Y.,Albrecht, B.K.,Bauer, D.,Bellon, S.F.,Boezio, A.,Boezio, C.,Broome, M.A.,Choquette, D.,Copeland, K.W.,Dussault, I.,Lewis, R.,Lin, M.H.,Lohman, J.,Liu, J.,Potashman, M.,Rex, K.,Shimanovich, R.,Whittington, D.A.,Vaida, K.R.,Harmange, J.C.; Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors.; J.Med.Chem., 58:2417-2430, 2015; PubMed: 25699405; DOI: 10.1021/jm501913a

実験手法

X-RAY DIFFRACTION (1.85 Å)