4XX0

CoA bound to pig GTP-specific succinyl-CoA synthetase

4XX0 の概要

• エントリーDOI: 10.2210/pdb4xx0/pdb
• 関連するPDBエントリー: 1EUC 1EUD 2FP4 2FPG 2FPI 2FPP
• 分子名称: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial, Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial, COENZYME A, ... (7 entities in total)
• 機能のキーワード: ligase, atp-grasp fold
• 由来する生物種: Sus scrofa (Pig); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77558.05

構造登録者

Fraser, M.E.,Huang, J.,Malhi, M. (登録日: 2015-01-29, 公開日: 2015-08-12, 最終更新日: 2024-11-13)

主引用文献

Huang, J.,Malhi, M.,Deneke, J.,Fraser, M.E.
Structure of GTP-specific succinyl-CoA synthetase in complex with CoA.
Acta Crystallogr.,Sect.F, 71:1067-1071, 2015

PubMed Abstract: Pig GTP-specific succinyl-CoA synthetase is an αβ-heterodimer. The crystal structure of the complex with the substrate CoA was determined at 2.1 Å resolution. The structure shows CoA bound to the amino-terminal domain of the α-subunit, with the free thiol extending from the adenine portion into the site where the catalytic histidine residue resides.

PubMed: 26249701
DOI: 10.1107/S2053230X15011188

実験手法

X-RAY DIFFRACTION (2.1 Å)