4XWY
Crystal structure of human sepiapterin reductase in complex with an N-acetylserotinin analogue
Summary for 4XWY
Entry DOI | 10.2210/pdb4xwy/pdb |
Related | 4HWK 4J7U 4J7X |
Descriptor | Sepiapterin reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide, ... (5 entities in total) |
Functional Keywords | oxidoreductase, inhibitor, complex |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P35270 |
Total number of polymer chains | 4 |
Total formula weight | 124461.12 |
Authors | Johnsson, K.,Hovius, R.,Gorszka, K.I.,Pojer, F. (deposition date: 2015-01-29, release date: 2015-07-01, Last modification date: 2024-01-10) |
Primary citation | Latremoliere, A.,Latini, A.,Andrews, N.,Cronin, S.J.,Fujita, M.,Gorska, K.,Hovius, R.,Romero, C.,Chuaiphichai, S.,Painter, M.,Miracca, G.,Babaniyi, O.,Remor, A.P.,Duong, K.,Riva, P.,Barrett, L.B.,Ferreiros, N.,Naylor, A.,Penninger, J.M.,Tegeder, I.,Zhong, J.,Blagg, J.,Channon, K.M.,Johnsson, K.,Costigan, M.,Woolf, C.J. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron, 86:1393-1406, 2015 Cited by PubMed: 26087165DOI: 10.1016/j.neuron.2015.05.033 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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