4XVE
17beta-HSD5 in complex with 3-pentyl-2-[(pyridin-2-ylmethyl)sulfanyl]-7-(pyrrolidin-1-ylcarbonyl)quinazolin-4(3H)-one
Summary for 4XVE
Entry DOI | 10.2210/pdb4xve/pdb |
Related | 4WDT 4WDU 4WDW 4WDX 4XVD |
Descriptor | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-pentyl-2-[(pyridin-2-ylmethyl)sulfanyl]-7-(pyrrolidin-1-ylcarbonyl)quinazolin-4(3H)-one, ... (4 entities in total) |
Functional Keywords | aldo-keto reductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39157.35 |
Authors | Amano, Y.,Yamaguchi, T. (deposition date: 2015-01-27, release date: 2015-04-15, Last modification date: 2023-11-08) |
Primary citation | Amano, Y.,Yamaguchi, T.,Niimi, T.,Sakashita, H. Structures of complexes of type 5 17 beta-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding. Acta Crystallogr.,Sect.D, 71:918-927, 2015 Cited by PubMed: 25849402DOI: 10.1107/S1399004715002175 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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