4WDW

17beta-HSD5 in complex with 3,6-dihydropyridin-1(2H)-yl(5-methyl-1H-indol-2-yl)methanone

Summary for 4WDW

Entry DOI	10.2210/pdb4wdw/pdb
Related	4WDS 4WDT 4WDU 4WDV 4WDX
Descriptor	Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,6-dihydropyridin-1(2H)-yl(5-methyl-1H-indol-2-yl)methanone, ... (4 entities in total)
Functional Keywords	aldo-keto reductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P42330
Total number of polymer chains	2
Total formula weight	77902.12
Authors	Amano, Y.,Yamaguchi, T. (deposition date: 2014-09-09, release date: 2015-04-15, Last modification date: 2024-05-29)
Primary citation	Amano, Y.,Yamaguchi, T.,Niimi, T.,Sakashita, H. Structures of complexes of type 5 17 beta-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding. Acta Crystallogr.,Sect.D, 71:918-927, 2015 Cited by PubMed: 25849402 DOI: 10.1107/S1399004715002175 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation