4XUA

Crystal Structure of the bromodomain of human BAZ2B in complex with E11919 BAZ2-ICR analogue

4XUA の概要

• エントリーDOI: 10.2210/pdb4xua/pdb
• 分子名称: Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, 4-{1-[2-(4-methyl-1H-1,2,3-triazol-1-yl)ethyl]-4-phenyl-1H-imidazol-5-yl}benzonitrile, ... (4 entities in total)
• 機能のキーワード: transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q9UIF8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14221.33

構造登録者

Chaikuad, A.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2015-01-25, 公開日: 2015-03-11, 最終更新日: 2024-01-10)

• 主引用文献: Drouin, L.,McGrath, S.,Vidler, L.R.,Chaikuad, A.,Monteiro, O.,Tallant, C.,Philpott, M.,Rogers, C.,Fedorov, O.,Liu, M.,Akhtar, W.,Hayes, A.,Raynaud, F.,Muller, S.,Knapp, S.,Hoelder, S.; Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.; J.Med.Chem., 58:2553-2559, 2015; PubMed: 25719566; DOI: 10.1021/jm501963e

実験手法

X-RAY DIFFRACTION (1.75 Å)